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Classification of Neutrophilia

Primary (no other evident associated disease)

  • Hereditary neutrophilia
  • Chronic idiopathic neutrophilia
  • Chronic myelogenous leukemia (CML) and other myeloproliferative diseases
  • Familial myeloproliferative disease
  • Congenital anomalies and leukemoid reaction
  • Leukocyte adhesion deficiency (LAD)
  • Familial cold urticaria and leukocytosis


  • Infection
  • Stress neutrophilia
  • Chronic inflammation
  • Drug induced: Steroids, lithium, tetracycline, G-CSF.
  • Nonhematologic malignancy
  • Generalized marrow stimulation as in hemolysis
  • Asplenia and hyposplenism

Related Criteria

Classification of Neutropenia

Serum Levels That Differentiate Anemia of Chronic Disease from Iron-Deficiency Anemia

Diagnostic Criteria for Disseminated Intravascular Coagulation (DIC)

Clinical Conditions Associated with Disseminated Intravascular Coagulation (DIC)

Diagnostic Criteria for Idiopathic Hypereosinophilic Syndrome (HES)

Diagnostic Criteria for Systemic Mastocytosis (SM)

WHO Classification of Mastocytosis

FAB Classification of Myelodysplastic Syndromes (MDS)

Diagnostic Criteria for Heparin-Induced Thrombocytopenia (HIT)



  1. Kyono W, Coates TD. A practical approach to neutrophil disorders. Pediatr Clin North Am. 2002 Oct;49(5):929-71, viii. [Medline]

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Created: October 23, 2005
Last Modified: 10/23/2010

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