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Clinical Conditions Associated with Disseminated Intravascular Coagulation (DIC)


1. Sepsis/severe infection (any microorganism)

2. Trauma (e.g., polytrauma, neurotrauma, fat embolism)

3. Organ destruction (e.g., severe pancreatitis)

4. Malignancy

  • solid tumors

  • myeloproliferative/lymphoproliferative malignancies

5. Obstetrical calamities

  • amniotic fluid embolism

  • abruptio placentae

6. Vascular abnormalities

  • Kasabach-Merritt syndrome

  • large vascular aneurysms

7. Severe hepatic failure

8. Severe toxic or immunologic reactions

  • snake bites

  • recreational drugs

  • transfusion reactions

  • transplant rejection

Related Criteria

Classification of Neutropenia

Classification of Neutrophilia

Serum Levels That Differentiate Anemia of Chronic Disease from Iron-Deficiency Anemia

Diagnostic Criteria for Disseminated Intravascular Coagulation (DIC)

Diagnostic Criteria for Idiopathic Hypereosinophilic Syndrome (HES)

Diagnostic Criteria for Systemic Mastocytosis (SM)

WHO Classification of Mastocytosis

FAB Classification of Myelodysplastic Syndromes (MDS)

Diagnostic Criteria for Heparin-Induced Thrombocytopenia (HIT)



1.      Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M; Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001 Nov;86(5):1327-30. [Medline]

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Created: August 04, 2005
Last Modified: 10/23/2010

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