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Criteria for Definite Diagnosis of Crohn's Disease

A. One of the following three conditions should be present:

  1. Intestinal longitudinal ulcer or deformity induced by a longitudinal ulcer or cobblestone pattern

  2. Intestinal small aphthous ulcerations arranged in a longitudinal fashion for at least three months, plus noncaseating granulomas

  3. Multiple small aphthous ulcerations in both the upper and lower digestive tract, not necessarily with longitudinal arrangement, for at least three months, plus noncaseating granulomas

B. The following diseases should be excluded:

  1. Ulcerative colitis

  2. Ischemic enterocolitis

  3. Acute infectious enterocolitis


Related Criteria

Appropriate Indications for Upper Gastrointestinal Endoscopy (UGE)

Diagnostic Criteria for Zollinger-Ellison Syndrome (ZES)

Diagnostic Criteria for Autoimmune Hepatitis (AIH)

Diagnostic Criteria for Wilson's disease

Severity Criteria for Acute Pancreatitis




  1. Yao T, Matsui T, Hiwatashi N. Crohn's disease in Japan: diagnostic criteria and epidemiology. Dis. Colon Rectum. 2000 Oct;43(10 Suppl):S85-93. [Medline]

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Created: Jul 18, 2007
Last Modified: 10/17/2010

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