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Diagnostic Criteria for Amiodarone-Induced Pulmonary Toxicity (APT)

The clinical diagnosis of amiodarone-induced pulmonary toxicity (APT) requires two or more of the following criteria:

  1. new onset of pulmonary symptoms such as dyspnea, cough, or pleuritic chest pain;

  2. new chest radiographic abnormality such as an interstitial or alveolar infiltrate;

  3. a decrease in the DLCO of 20% from the pretreatment value, or if none is available, a value less than 80% of predicted;

  4. abnormal lung uptake with gallium-67 radioisotope; and

  5. characteristic histologic changes of lung tissue obtained by bronchoscopic or open lung biopsy.

Exclusion of alternative etiologies such as congestive heart failure, infection, or malignancy.

DLCO= diffusion capacity of the lung for carbon monoxide



Related Criteria

NYHA Functional Classification for Congestive Heart Failure

Framingham Criteria for Congestive Heart Failure

Cardiovascular Major Risk Factors

Duke Criteria for Infective Endocarditis (IE)

Revised Jones Criteria for Acute Rheumatic Fever (ARF)

Wells Clinical Prediction Rule for Pulmonary Embolism and Deep Venous Thrombosis

Braunwald Classification of Unstable Angina (UA)




  1. Dusman RE, Stanton MS, Miles WM, Klein LS, Zipes DP, Fineberg NS, Heger JJ. Clinical features of amiodarone-induced pulmonary toxicity. Circulation. 1990 Jul;82(1):51-9. [Medline]

  2. Camus P, Martin WJ 2nd, Rosenow EC 3rd. Amiodarone pulmonary toxicity. Clin Chest Med. 2004 Mar;25(1):65-75. [Medline]

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Created: Nov 06, 2006
Last Modified: 10/17/2010

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