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Harrison's Principles of Internal Medicine - 19th Edition (April 17, 2015)

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Histologic Scoring Systems for Chronic Liver Disease Print E-mail
Written by G. Firman MD   
Tuesday, 23 June 2015 04:47


Grading and staging refers to a semiquantitative assessment of the necroinflammatory activity (grade) and degree of fibrosis (stage) in relation to chronic hepatitis.

Last Updated on Friday, 26 June 2015 07:22
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Diagnostic Criteria of Familial Mediterranean Fever (FMF) Print E-mail
Written by G. Firman MD   
Monday, 22 June 2015 05:51


The diagnosis of familial Mediterranean fever (FMF) is based upon three factors: typical clinical manifestations, a positive response to colchicine therapy, and genetic testing, although currently available tests do not detect all mutations associated with FMF.

Last Updated on Tuesday, 23 June 2015 04:27
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Alvarado Score for Acute Appendicitis Print E-mail
Written by G. Firman MD   
Thursday, 14 May 2015 03:29


The use of the Alvarado scoring system, which includes clinical examination findings and laboratory values, is helpful in ruling out appendicitis. Scores range from 1 to 10, with higher scores indicating a greater risk of appendicitis. When the score is less than 4, appendicitis is uncommon, and imaging and other interventions can be avoided.

Last Updated on Monday, 18 May 2015 07:57
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Diagnosis of Inflammatory Myopathies Print E-mail
Written by G. Firman MD   
Wednesday, 13 May 2015 06:40


The diagnosis of the exact subtype of inflammatory myopathy is based on the combination of clinical history, tempo of disease progression, pattern of muscle involvement, muscle enzyme levels, electromyographic findings, muscle-biopsy analysis, and for some conditions, the presence of certain autoantibodies.

Last Updated on Friday, 12 June 2015 07:49
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Tumor Markers in Clinical Practice Print E-mail
Written by G. Firman MD   
Wednesday, 11 March 2015 04:41


Tumor markers are playing an increasingly important role in cancer detection and management. These laboratory-based tests are potentially useful in screening for early malignancy, aiding cancer diagnosis, determining prognosis, surveillance following curative surgery for cancer, up front predicting drug response or resistance, and monitoring therapy in advanced disease.

Last Updated on Wednesday, 13 May 2015 06:43
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