PGL, progressive generalized lymphadenopathy.

Clinical Categories of HIV Infection

Category A: Consists of one or more of the conditions listed below in an adolescent or adult (>13 years) with documented HIV infection.

Conditions listed in categories B and C must not have occurred.

• Asymptomatic HIV infection

• Persistent generalized lymphadenopathy

• Acute (primary) HIV infection with accompanying illness or history of acute HIV infection

Category B: Consists of symptomatic conditions in an HIV-infected adolescent or adult that are not included among conditions listed in clinical category C and that meet at least one of the following criteria: (1) The conditions are attributed to HIV infection or are indicative of a defect in cell-mediated immunity; or (2) the conditions are considered by physicians to have a clinical course or to require management that is complicated by HIV infection. Examples include, but are not limited to, the following:

• Bacillary angiomatosis

• Candidiasis, oropharyngeal(thrush)

• Candidiasis, vulvovaginal; persistent, frequent, or poorly responsive to therapy

• Cervical dysplasia (moderate or severe)/cervical carcinoma in situ

• Constitutional symptoms, such as fever (38.5°C) or diarrhea lasting >1 month

• Hairy leukoplakia, oral

• Herpes zoster (shingles), involving at least two distinct episodes or more than one dermatome

• Idiopathic thrombocytopenic purpura

• Listeriosis

• Pelvic inflammatory disease, particularly if complicated by tuboovarian abscess

• Peripheral neuropathy

Category C: Conditions listed in the AIDS surveillance case definition.

• Candidiasis of bronchi, trachea, or lungs

• Candidiasis, esophageal

• Cervical cancer, invasive

• Coccidioidomycosis, disseminated or extrapulmonary

• Cryptococcosis, extrapulmonary

• Cryptosporidiosis, chronic intestinal (>1 month’s duration)

• Cytomegalovirus disease (other than liver, spleen, or nodes)

• Cytomegalovirus retinitis (with loss of vision)

• Encephalopathy, HIV-related

• Herpes simplex: chronic ulcer(s) (>1 month’s duration); or bronchitis, pneumonia, or esophagitis

• Histoplasmosis, disseminated or extrapulmonary

• Isosporiasis, chronic intestinal (>1 month’s duration)

• Kaposi’s sarcoma

• Lymphoma, Burkitt’s (or equivalent term)

• Lymphoma, primary, of brain

• Mycobacterium avium complex or M. kansasii, disseminated or extrapulmonary

• Mycobacterium tuberculosis, any site (pulmonary or extrapulmonary)

• Mycobacterium, other species or unidentified species, disseminated or extrapulmonary

• Pneumocystis carinii pneumonia

• Pneumonia, recurrent

• Progressive multifocal leukoencephalopathy

• Salmonella septicemia, recurrent

• Toxoplasmosis of brain

• Wasting syndrome due to HIV

References:

1. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Recomm Rep. 1992 Dec 18;41(RR-17):1-19. [Medline]

Created: Mar 26, 2007