Harrison's Principles of Internal Medicine - 19th Edition (April 17, 2015)
|FAB Classification of Myelodysplastic Syndromes (MDS)|
|Written by G. Firman MD|
|Sunday, 01 March 2009 18:28|
Refractory anemia (RA).
Refractory anemia with ringed sideroblasts (RARS)
Refractory anemia with excess blasts (RAEB)
Chronic myelomonocytic leukaemia (CML)
Refractory anemia with excess blasts in transformation (RAEB-T)
International Prognostic Scoring System for Myelodysplastic Syndromes
The overall score is the sum of the scores for bone marrow blasts, karyotype, and cytopenias. The percentage of blasts is scored as follows: <5 percent, 0; 5 to 10 percent, 0.5; 11 to 20 percent, 1.5; and 21 to 30 percent, 2.0. Cytogenetic features associated with a good prognosis (normal karyotype, Y-, 5q-, or 20q-) are scored as 0; those associated with a poor prognosis (abnormal chromosome 7 or three or more abnormalities) are scored as 1.0; and all other cytogenetic abnormalities, which are associated with an intermediate prognosis, are scored as 0.5. A score of 0 is assigned if the patient has no cytopenia or only one type, and a score of 0.5 is assigned if the patient has two or three types of cytopenia. The various types of cytopenia are defined as follows: hemoglobin, <10 g per deciliter; absolute neutrophil count, <1500 per cubic millimeter; and platelet count, <100,000 per cubic millimeter.
Created: March 13, 2006
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|Last Updated on Thursday, 28 August 2014 06:03|
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