English (United Kingdom)Español (spanish formal Internacional)

MC Facebook


Home Criteria Infectious Disease Definitions of Clostridium difficile Infection (CDI)


The content of this website is provided for general informational purposes only and is not a substitute professional medical advice

Definitions of Clostridium difficile Infection (CDI) Print E-mail
User Rating: / 0
Written by G. Firman MD   
Thursday, 29 December 2016 07:02

Clostridium difficile ( C. difficile ) is a Gram-positive, sporeforming bacterium usually spread by the fecal-oral route. It is non-invasive and produces toxins A and B that cause disease, ranging from asymptomatic carriage, to mild diarrhea, to colitis, or pseudomembranous colitis. CDI is defined as the acute onset of diarrhea with documented toxigenic C. difficile or its toxin and no other documented cause for diarrhea. 

Definitions of Clostridium difficile Infection (CDI)

Use of standardized definitions for CDI (health-care onset-health-care facility associated (HO-HCFA), community onset-health-care facility associated (CO-HCFA), community associated (CA), or indeterminate disease (ID) will allow comparison among studies. 

Type of case


Health-care facility-onset health-care facility associated (HO-HCFA)

Occurs when onset of symptoms 3 days after admission to a health-care facility.

Community onset healthcare facility associated (CO-HCFA)

Onset of symptoms within 4 weeks after being discharged from a health-care facility.

Community associated (CA)

Occurs when onset of symptoms occurs outside a health-care facility or < 3 days after admission to a health-care facility and has not been discharged from a healthcare facility in the previous 12 weeks.

Indeterminate or unknown onset (ID)

CDI develops after being discharged from a health-care facility 4 – 12 weeks previously.

Recurrent CDI

Episode of CDI that occurs 8 weeks after the onset of a previous episode, provided the symptoms from the previous episode resolved.


  1. Surawicz CM, Brandt LJ, Binion DG, Ananthakrishnan AN, Curry SR, Gilligan PH, McFarland LV, Mellow M, Zuckerbraun BS. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am J Gastroenterol. 2013 Apr;108(4):478-98. [Medline]
  2. Bagdasarian N, Rao K, Malani PN. Diagnosis and treatment of Clostridium difficile in adults: a systematic review. JAMA. 2015 Jan 27;313(4):398-408. [Medline]

Created Jan 05, 2017.

Last Updated on Thursday, 05 January 2017 06:07

Free Registry



HONcode accreditation seal. We comply with the HONcode standard for health trust worthy information:
verify here

Site Last Modified

Wednesday 17 January 2018, 14:29


Copyright © 2005-2018. All Rights Reserved