Alarcon-Segovia Diagnostic Criteria for Mixed Connective Tissue Disease (MCTD)

1. Serological criteria: Positive anti U1 RNP at haemagglutination titer >1:1600

2. Clinical criteria:

1. Oedema of hands

2. Synovitis

3. Myositis

4. Raynaud´s

5. Acrosclerosis

 

Requirements:

1. Serological

2. At least 3 clinical features

3. Association of hand oedema, Raynaud´s and acrosclerosis requires at least one other feature

 

Kusukawa Diagnostic Criteria for Mixed Connective Tissue Disease (MCTD)

Common Symptoms

1. Reynaud´s Phenomenon

2. Swollen fingers or hands

Presence of Anti U1 RNP

Mixed findings

A. Systemic lupus erythematosus (SLE) like

• Polyarthritis

• Pericarditis/pleuritis

• Lymphadenopathy

• Facial erithema

• Leucopenia/thrombocytopenia

B. Scleroderma like

• Sclerodactyly

• Pulmonary fibrosis

• Esophageal dysmotility

C. Polymyositis like

• Muscle weakness

• High creatine phosphokinase (CPK)

• Myophatic electromyogram (EMG)

Requirement for diagnosis: At least one common symptom, with positive U1 RNP antibodies and one or more findings in at least two of the three categories A, B, and C.

 

 

References:

1. Alarcon-Segovia D, Cardiel MH. Comparison between 3 diagnostic criteria for mixed connective tissue disease. Study of 593 patients. J Rheumatol. 1989 Mar;16(3):328-34. [Medline]

2. Alarcon-Segovia D. Mixed connective tissue disease and overlap syndromes. Clin Dermatol. 1994 Apr-Jun;12(2):309-16. [Medline]

3. Tiddens HA, van der Net JJ, de Graeff-Meeder ER, Fiselier TJ, de Rooij DJ, van Luijk WH, Herzberger R, van Suijlekom LW, van Venrooij WJ, Zegers BJ, et al. Juvenile-onset mixed connective tissue disease: longitudinal follow-up. J Pediatr. 1993 Feb;122(2):191-7. [Medline]

4. Haroon N, Nisha RS, Chandran V, Bharadwaj A. Pulmonary hypertension not a major feature of early mixed connective tissue disease: A prospective clinicoserological study. J Postgrad Med. 2005 Apr-Jun;51(2):104-8. [Medline]