Alarcon-Segovia Diagnostic Criteria for Mixed Connective Tissue Disease (MCTD)

1. Serological criteria: Positive anti U1 RNP at haemagglutination titer >1:1600

2. Clinical criteria:

1. Oedema of hands

2. Synovitis

3. Myositis

4. Raynaud´s

5. Acrosclerosis

Requirements:

1. Serological

2. At least 3 clinical features

3. Association of hand oedema, Raynaud´s and acrosclerosis requires at least one other feature

Kusukawa Diagnostic Criteria for Mixed Connective Tissue Disease (MCTD)

Common Symptoms

1. Reynaud´s Phenomenon

2. Swollen fingers or hands

Presence of Anti U1 RNP

Mixed findings

A. Systemic lupus erythematosus (SLE) like

• Polyarthritis

• Pericarditis/pleuritis

• Lymphadenopathy

• Facial erithema

• Leucopenia/thrombocytopenia

B. Scleroderma like

• Sclerodactyly

• Pulmonary fibrosis

• Esophageal dysmotility

C. Polymyositis like

• Muscle weakness

• High creatine phosphokinase (CPK)

• Myophatic electromyogram (EMG)

Requirement for diagnosis: At least one common symptom, with positive U1 RNP antibodies and one or more findings in at least two of the three categories A, B, and C.
 

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