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ACR Criteria for the Classification of Churg-Strauss Syndrome (CSS)

American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (CSS). Classified as CSS if at least four of six criteria are present

  1. Asthma: History of wheezing or diffuse high-pitched expiratory rhonchi.
  2. Eosinophilia: Eosinophilia >10% on differential white blood cell count.
  3. Mono- or polyneuropathy: Development of mononeuropathy, multiple mononeuropathies, or polyneuropathy (glove/ stocking distribution) attributable to systemic vasculitis.
  4. Pulmonary infiltrates, non-fixed: Migratory or transitory pulmonary infiltrates (not including fixed infiltrates). attributable to vasculitis.
  5. Paranasal sinus abnormality: History of acute or chronic paranasal sinus pain or tenderness or radiographic opacification of the paranasal sinuses.
  6. Extravascular eosinophils: Biopsy including artery, arteriole or venule showing accumulations of eosinophils in extravascular areas.

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References:

  1. Masi AT, Hunder GG, Lie JT, Michel BA, Bloch DA, Arend WP, Calabrese LH, Edworthy SM, Fauci AS, Leavitt RY, et al. The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis). Arthritis Rheum. 1990 Aug;33(8):1094-100. [Medline]

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Created: May 29, 2005
Last Modified: 10/24/2010

 
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