MASCC Index Score for Identifying Low-Risk Febrile Neutropenic Cancer Patients

MASCC Index Score for Identifying Low-Risk Febrile Neutropenic Cancer Patients

Scoring system for risk of complications among febrile neutropenic patients, based on the Multinational Association for Supportive Care in Cancer (MASCC) predictive model.

Characteristic	Point score
Burden of illness No or mild symptoms Moderate symptoms	5 3
No hypotension	5
No chronic obstructive pulmonary disease	4
Solid tumor or no previous fungal infection in hematologic tumor	4
Outpatient status	3
No dehydration	3
Aged <60 years	2

The maximum value in this system is 26, and a score of <21 predicts a <5% risk for severe complications and a very low mortality (<1%) in febrile neutropenic patients.

References:

Klastersky J. Management of fever in neutropenic patients with different risks of complications. Clin Infect Dis. 2004 Jul 15;39 Suppl 1:S32-7. [Medline]
Antoniadou A, Giamarellou H. Fever of unknown origin in febrile leukopenia. Infect Dis Clin North Am. 2007 Dec;21(4):1055-90. [Medline]