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Principles and Practice of Infectious Diseases: 2-Volume Set, by Gerald L. Mandell
6th edition (October 22, 2004)
The Sanford Guide to Antimicrobial Therapy, 2006, by David N., MD. Gilbert
36th edition (March 2006)
Current Diagnosis & Treatment In Infectious Diseases (Current Diagnosis and Treatment in Infectious Disease), by Walter R. Wilson
2nd edition (August 15, 2005)
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Classification of Fever of Unknown
Origin (FUO)
|
Category
of FUO |
Definition |
Common
etiologies |
|
Classic |
Temperature
>38.3°C (100.9°F)
Duration of >3 weeks
Evaluation of at least 3
outpatient visits or 3 days in
hospital |
Infection,
malignancy, collagen vascular
disease |
|
Nosocomial |
Temperature
>38.3°C
Patient hospitalized >=24 hours
but no fever or incubating on
admission
Evaluation of at least 3 days |
Clostridium
difficile
enterocolitis, drug-induced,
pulmonary embolism, septic
thrombophlebitis, sinusitis |
|
Immune
deficient (neutropenic) |
Temperature
>38.3°C
Neutrophil count <=500 per mm3
Evaluation of at least 3 days |
Opportunistic bacterial
infections, aspergillosis,
candidiasis, herpes virus |
|
HIV-associated |
Temperature
>38.3°C
Duration of >4 weeks for
outpatients, >3 days for
inpatients
HIV infection confirmed |
Cytomegalovirus,
Mycobacterium
avium-intracellulare complex,
Pneumocystis carinii
pneumonia, drug-induced,
Kaposi's sarcoma, lymphoma |
HIV = human
immunodeficiency virus.
Common Etiologies
of Fever of Unknown Origin
Infections
-
Tuberculosis (especially
extrapulmonary)
- Abdominal
abscesses
- Pelvic
abscesses
- Dental
abscesses
-
Endocarditis
-
Osteomyelitis
- Sinusitis
-
Cytomegalovirus
-
Epstein-Barr virus
- Human
immunodeficiency virus
- Lyme
disease
- Prostatitis
- Sinusitis
Malignancies
- Chronic
leukaemia
- Lymphoma
- Metastatic
cancers
- Renal cell
carcinoma
- Colon
carcinoma
- Hepatoma
-
Myelodysplastic syndromes
- Pancreatic
carcinoma
- Sarcomas
Autoimmune
conditions
- Adult
Still's disease
- Polymyalgia
rheumatica
- Temporal
arteritis
- Rheumatoid
arthritis
- Rheumatoid
fever
-
Inflammatory bowel disease
- Reiter's
syndrome
- Systemic
lupus erythematosus
-
Vasculitides
Miscellaneous
-
Drug-induced fever
-
Complications from cirrhosis
- Factitious
fever
- Hepatitis
(alcoholic, granulomatous, or
lupoid)
- Deep venous
thrombosis
- Sarcoidosis
Related Criteria
Case
Definition of Staphylococcal Toxic
Shock Syndrome (TSS)
Case Definition of Streptococcal
Toxic-Shock Syndrome (Streptococcal TSS)
and Necrotizing Fasciitis
More...
References:
-
Durack DT, Street AC. Fever of
unknown origin--reexamined and
redefined. Curr Clin Top Infect Dis.
1991;11:35-51.
[Medline]
-
Hirschmann JV.
Fever of unknown origin in adults.
Clin Infect
Dis. 1997 Mar;24(3):291-300
[Medline]
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Created: July 04, 2006
Last Modified:
10-29-2007 |
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