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Diagnostic Criteria for Disseminated Intravascular Coagulation (DIC)
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Classification
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Definition
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Diagnostic criteria
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Biological DIC
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Hemostatic defect without clinical manifestations
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Elevated D-Dimers
and
1 major criterion for consumption of platelets or coagulation factors
or
2 minor criteria for consumption of platelets or coagulation factors
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Clinical DIC
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Hemostatic defect with hemorrhagic or ischemic manifestations
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Same as above + microvascular bleeding and/or thrombosis
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Complicated DIC
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Hemostatic defect with hemorrhagic or ischemic manifestations that jeopardize organ function or patient prognosis
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Same as above + organ failure (single or multiple)
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Details of laboratory criteria
D-Dimers greater than 500 µg·L–1
Platelet consumption
-
Minor: platelet count between 50 and 100,000·/mm3
-
Major: platelet count less than 50,000·/mm3
Consumption of coagulation factors
INR of the PT = international normalized ratio of the prothrombin time. The elevation of D-Dimers is not specific to DIC. Similarly, the clinical manifestations of DIC are not specific.
Related Criteria:
Clinical Conditions Associated with Disseminated Intravascular Coagulation (DIC)
Diagnostic Criteria for Sepsis
Definitions for
the Terms
Bacteremia,
Sepsis, Severe
Sepsis, Septic
Shock, and Other
Related
Disorders
Diagnostic Criteria for Disseminated Intravascular Coagulation (DIC)
Diagnostic
Criteria for
Adult
Respiratory
Distress
Syndrome (ARDS)
More...
References;
- Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M; Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001 Nov;86(5):1327-30. [Medline]
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Wintrobe's Clinical Hematology, 11th edition (November 1, 2003)
Hematology: Basic Principles And Practice, by Ronald Hoffman
4th Bk&Cdr edition (December 3, 2004)
Clinical Diagnosis and Management by Laboratory Methods, by John Bernard Henry
20th edition (April, 2001)
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