|
Classification
|
Definition
|
Diagnostic criteria
|
|
Biological DIC
|
Hemostatic defect without clinical manifestations
|
Elevated D-Dimers
and
1 major criterion for consumption of platelets or coagulation factors
or
2 minor criteria for consumption of platelets or coagulation factors
|
|
Clinical DIC
|
Hemostatic defect with hemorrhagic or ischemic manifestations
|
Same as above + microvascular bleeding and/or thrombosis
|
|
Complicated DIC
|
Hemostatic defect with hemorrhagic or ischemic manifestations that jeopardize organ function or patient prognosis
|
Same as above + organ failure (single or multiple)
|
Details of laboratory criteria
D-Dimers greater than 500 µg·L–1
Platelet consumption
-
Minor: platelet count between 50 and 100,000·/mm3
-
Major: platelet count less than 50,000·/mm3
Consumption of coagulation factors
INR of the PT = international normalized ratio of the prothrombin time. The elevation of D-Dimers is not specific to DIC. Similarly, the clinical manifestations of DIC are not specific.
