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2001 Bethesda System
Terminology
Specimen
Type: Indicate conventional
smear (Pap smear) vs. liquid
based vs. other
Specimen
Adequacy
-
Satisfactory for evaluation
(describe presence or absence
of endocervical/transformation
zone component and any other
quality indicators, e.g.,
partially obscuring blood,
inflammation, etc.)
-
Unsatisfactory for evaluation
... (specify reason)
-
Specimen
rejected/not processed
(specify reason)
-
Specimen
processed and examined, but
unsatisfactory for evaluation
of epithelial abnormality
because of (specify reason)
General
Categorization (optional)
-
Negative
for intraepithelial lesion or
malignancy
-
Epithelial
cell abnormality: See
interpretation/result (specify
‘squamous’ or ‘glandular’ as
appropriate)
-
Other: See
interpretation/result (e.g.
endometrial cells in a woman
> 40 years of age)
Automated
Review
If case
examined by automated device,
specify device and result.
Ancillary
Testing
Provide a
brief description of the test
methods and report the result so
that it is easily understood by
the clinician.
Interpretation/Result
Negative
for Intraepithelial Lesion or
Malignancy (when there is no
cellular evidence of neoplasia,
state this in the General
Categorization above and/or in
the Interpretation/Result
section of the report, whether
or not there are organisms or
other non-neoplastic findings)
Organisms:
-
Trichomonas
vaginalis
-
Fungal
organisms morphologically
consistent with Candida
species
-
Shift in
flora suggestive of bacterial
vaginosis
-
Bacteria
morphologically consistent
with Actinomyces species.
-
Cellular
changes consistent with Herpes
simplex virus
Other non
neoplastic findings (Optional to
report; list not inclusive):
-
Reactive
cellular changes associated
with
-
inflammation (includes typical
repair)
-
radiation
-
intrauterine
contraceptive device (IUD)
-
Glandular
cells status post hysterectomy
-
Atrophy
Other
Epithelial
Cell Abnormalities
SQUAMOUS CELL
-
Atypical
squamous cells (ASC)
-
of
undetermined significance (ASC-US)
-
cannot
exclude HSIL (ASC-H)
-
Low grade
squamous intraepithelial
lesion (LSIL)
encompassing: HPV/mild
dysplasia/cervical
intraepithelial neoplasia (CIN)
1
-
High grade
squamous intraepithelial
lesion (HSIL)
encompassing: moderate and
severe dysplasia, carcinoma in
situ (CIS)/CIN 2 and CIN 3
-
with
features suspicious for
invasion (if invasion is
suspected)
-
Squamous
cell carcinoma
GLANDULAR
CELL
-
Atypical
-
endocervical cells (NOS or
specify in comments)
-
endometrial
cells (NOS or specify in
comments)
-
glandular
cells (NOS or specify in
comments)
-
Atypical
-
endocervical cells, favor
neoplastic
-
glandular
cells, favor neoplastic
-
Endocervical
adenocarcinoma in situ (AIS)
-
Adenocarcinoma
-
endocervical
-
endometrial
-
extrauterine
-
not
otherwise specified (NOS)
Other
Malignant Neoplasms:
(specify)
Educational Notes and
Suggestions (optional)
Suggestions
should be concise and consistent
with clinical follow-up
guidelines published by
professional organizations
(references to relevant
publications may be included).
Related Criteria
CDC Diagnostic Criteria for the Diagnosis of Pelvic Inflammatory Disease (PID)
Diagnostic Criteria in Polycystic Ovary Syndrome (PCOS)
Syndromes or Disease Entities That Have Been Associated with Polycystic Ovaries
References:
-
Solomon D, Davey D,
Kurman R, Moriarty A,
O'Connor D, Prey M, Raab
S, Sherman M,
Wilbur D, Wright T Jr,
Young N; Forum Group
Members; Bethesda 2001
Workshop.
The
2001 Bethesda System:
terminology for
reporting results of
cervical
cytology. JAMA. 2002 Apr
24;287(16):2114-9.
[Medline]
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Te Linde's Operative Gynecology, by Howard W., Iii, Md. Jones, et al
9th edition (July 1, 2003)
Novak's Gynecology, by Paula A. Hillard
13th edition (August 15, 2002)
Operative Obstetrics, by Larry C. Gilstrap
2nd edition (March 26, 2002)
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