Acetaminophen-induced disease

Arterial pH <7.3 (irrespective of the grade of encephalopathy)

or

Grade III or IV encephalopathy, and

Prothrombin time >100 seconds, and

Serum creatinine >3.4mg/dl (301 μmol/L)

All other causes of fulminant hepatic failure

Prothrombin time >100 seconds (irrespective of the grade of encephalopathy)

Or

Any three of the following variables (irrespective of the grade of encephalopathy)

1. Age <10 years or >40 years

2. Etiology: non-A, non-B hepatitis, halothane hepatitis, idiosyncratic drug reactions

3. Duration of jaundice before onset of encephalopathy >7 days

4. Prothrombin time >50 seconds

5. Serum bilirrubin >18 mg/dl (308 μmol/L)