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Serum Levels That Differentiate Anemia of Chronic Disease from Iron-Deficiency Anemia

Variable

Anemia of Chronic Disease

Iron-Deficiency Anemia

Both Conditions

Iron

Reduced

Reduced

Reduced

Trasnferrin

Reduced to normal

Increased

Reduced

Transferrin saturation

Reduced

Reduced

Reduced

Ferritin

Normal to increased

Reduced

Reduced to normal

Soluble transferrin receptor

Normal

Increased

Normal to increased

Ratio of soluble transferrin receptor to log ferritin

Low (<1)

High (>2)

High (>2)

Cytokine Levels

Increased

Normal

Increased

Patients with both conditions include those with anemia of chronic disease and true iron deficiency.

Related Criteria

Classification of Neutropenia

Classification of Neutrophilia

Diagnostic Criteria for Disseminated Intravascular Coagulation (DIC)

Clinical Conditions Associated with Disseminated Intravascular Coagulation (DIC)

Diagnostic Criteria for Idiopathic Hypereosinophilic Syndrome (HES)

Diagnostic Criteria for Systemic Mastocytosis (SM)

WHO Classification of Mastocytosis

FAB Classification of Myelodysplastic Syndromes (MDS)

Diagnostic Criteria for Heparin-Induced Thrombocytopenia (HIT)

More...

Reference:

  1. Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005 Mar 10;352(10):1011-23. [Medline]

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Created: May 03, 2005
Last Modified: 10/17/2010

 
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